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Previous Volume 352:1131-1132 March 17, 2005 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Solomon, S. D. Related Article by Nussmeier, N. A. Related Article by Bresalier, R. S. PubMed Citation

This issue of the Journal contains three articles about the adverse cardiovascular effects of agents that selectively inhibit one form of prostaglandin endoperoxide synthase, commonly known as cyclooxygenase-2 (COX-2).^1,2,3 This is part of a long bench-to-bedside story with an adverse outcome that was not widely anticipated at its start. Unfortunately, as the evidence began to suggest unexpected toxicity of this group of agents, the same zeal that had driven the clinical investigation to show their gastrointestinal safety was not evidenced by studies designed to show their cardiovascular safety.

In 1987, evidence emerged⁴ that there were probably two enzymes — cyclooxygenase-1 . . . [Full Text of this Article]

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This article was published at www.nejm.org on February 15, 2005.

Related Letters:

Cardiovascular Risk Associated with Celecoxib
Brophy J. M., Solomon S. D., Wittes J., McMurray J., the APC Study Cardiovascular Safety Committee and Investigators , Psaty B. M., Furberg C. D.
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N Engl J Med 2005; 352:2648-2650, Jun 23, 2005. Correspondence

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