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Previous Volume 358:2829-2831 June 26, 2008 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Almost three decades ago, Victor McKusick and I reviewed Marfan's syndrome in the Journal and advised traditional medical and surgical approaches to management.¹ The holy grail at that time was the cause of this autosomal dominant condition, based on the common presumption that understanding the cause would lead directly to effective therapy. In fact, life expectancy improved dramatically in subsequent years for all but the most severely affected patients, despite a lack of understanding of the underlying connective-tissue defect.² Dissection of the aorta was and remains the most common cause of death. However, the evolution of ever more effective surgical . . . [Full Text of this Article]

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From the Center for the Integration of Genetic Healthcare Technologies, Departments of Medicine and Genetics, University of Pennsylvania School of Medicine, Philadelphia.

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