FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 361:718-719 August 13, 2009 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

Ovulation, initiated by the proestrus surge of the pituitary luteinizing hormone, culminates in the rupture of the ovarian follicle and is followed by the delivery of a mature oocyte. This event, an essential prelude to fertilization, has long piqued curiosity and is a focus of research in reproduction. Fan et al.¹ recently found that two signaling molecules — extracellular signal–regulated kinases 1 and 2 (Erk1 and Erk2) — are critical to luteinizing hormone–induced ovulation in mice.

The ovulatory response in mammals represents a complex series of events consisting of at least four distinct components: the resumption of meiosis (also known . . . [Full Text of this Article]

Source Information

From the Department of Biological Regulation, the Weizmann Institute, Rehovot, Israel.

HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  TERMS OF USE  |  HELP  |  beta.nejm.org Comments and questions? Please contact us. The New England Journal of Medicine is owned, published, and copyrighted © 2010 Massachusetts Medical Society. All rights reserved.