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Previous Volume 349:716-717 August 14, 2003 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The genes encoding the two major connexins of the cochlea are contiguous on human chromosome 13 (GJB2 and GJB6) and on mouse chromosome 14 (Cx26 and Cx30, respectively). Biallelic GJB2 mutations account for a large proportion of cases of recessive deafness in many European countries,¹ whereas biallelic mutations of GJB6 appear to be involved only rarely. However, del Castillo et al.² have shown that a significant proportion of people who have severe or profound prelingual deafness carry both a deleterious point mutation in GJB2 on one chromosome and a large deletion (approximately 340 kb) in GJB6, but . . . [Full Text of this Article]

This article has been cited by other articles:

• del Castillo, F J, Rodriguez-Ballesteros, M, Alvarez, A, Hutchin, T, Leonardi, E, de Oliveira, C A, Azaiez, H, Brownstein, Z, Avenarius, M R, Marlin, S, Pandya, A, Shahin, H, Siemering, K R, Weil, D, Wuyts, W, Aguirre, L A, Martin, Y, Moreno-Pelayo, M A, Villamar, M, Avraham, K B, Dahl, H-H M, Kanaan, M, Nance, W E, Petit, C, Smith, R J H, Van Camp, G, Sartorato, E L, Murgia, A, Moreno, F, del Castillo, I (2005). A novel deletion involving the connexin-30 gene, del(GJB6-d13s1854), found in trans with mutations in the GJB2 gene (connexin-26) in subjects with DFNB1 non-syndromic hearing impairment. J. Med. Genet. 42: 588-594 [Full Text]  
• Marlin, S., Feldmann, D., Blons, H., Loundon, N., Rouillon, I., Albert, S., Chauvin, P., Garabedian, E.-N., Couderc, R., Odent, S., Joannard, A., Schmerber, S., Delobel, B., Leman, J., Journel, H., Catros, H., Lemarechal, C., Dollfus, H., Eliot, M.-M., Delaunoy, J.-L., David, A., Calais, C., Drouin-Garraud, V., Obstoy, M.-F., Goizet, C., Duriez, F., Fellmann, F., Helias, J., Vigneron, J., Montaut, B., Matin-Coignard, D., Faivre, L., Baumann, C., Lewin, P., Petit, C., Denoyelle, F. (2005). GJB2 and GJB6 Mutations: Genotypic and Phenotypic Correlations in a Large Cohort of Hearing-Impaired Patients. Arch Otolaryngol Head Neck Surg 131: 481-487 [Abstract] [Full Text]