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Volume 351:2791-2792 December 30, 2004 Number 27
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Altered Nuclear Transfer in Stem-Cell Research — A Flawed Proposal
Douglas A. Melton, Ph.D., George Q. Daley, M.D., Ph.D., and Charles G. Jennings, Ph.D.

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The study of human embryonic stem cells is a matter of intense public debate, primarily because derivation of such cells requires the destruction of human blastocysts, a procedure that some find morally objectionable. William Hurlbut, M.D., of Stanford University and a member of the President's Council on Bioethics has recently proposed to the council an alternative way to derive embryonic stem cells that, he argues, circumvents this objection.1 The chair of the council, Leon Kass, M.D., Ph.D., favors Hurlbut's proposal.2 We believe that it is flawed.

Hurlbut's proposal is based on the observation that mouse embryos carrying a mutation in . . . [Full Text of this Article]


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Dr. Melton is codirector, Dr. Daley a member of the executive committee, and Dr. Jennings executive director of the Harvard Stem Cell Institute. Dr. Melton is a professor of molecular and cellular biology and an investigator of the Howard Hughes Medical Institute at Harvard University, and Dr. Daley is an associate professor of biologic chemistry and molecular pharmacology at Harvard Medical School and of pediatrics at Children's Hospital, Boston.


Related Letters:

Altered Nuclear Transfer
Hurlbut W. B., Melton D. A., Daley G. Q., Jennings C. G.
Extract | Full Text | PDF  
N Engl J Med 2005; 352:1153-1154, Mar 17, 2005. Correspondence

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