The Janus kinase (JAK)–signal transducer and activatorof transcription (STAT) signaling pathway has emerged over thepast decade as a major relay between cell-surface receptorsand cytokine responses. The human genome encodes four JAK familymembers — JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2)— and seven STAT proteins.1 JAKs are protein tyrosinekinases that interact with the intracellular domains of cytokinereceptors (Figure 1) and that have enhanced catalytic activitytoward substrate proteins after receptor activation. The primaryJAK substrates are STAT proteins — latent transcriptionfactors that require their tyrosine residues, and sometimesserine residues, . . . [Full Text of this Article]
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From the Department of Pathology, New York University School of Medicine, New York.
This article (10.1056/NEJMe078197) was published at www.nejm.org on September 19, 2007.
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