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Editorial
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Volume 360:724-725 February 12, 2009 Number 7
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Not an HIV Cure, but Encouraging New Directions
Jay A. Levy, M.D.

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 by Hütter, G.
-PubMed Citation
The history of infectious diseases frequently includes people who were resistant to a pathogen. Such a phenomenon helped the Spanish, who had resistance to smallpox, in their conquest of South America, but not the Aztecs or the Incas, who had no resistance to smallpox and were decimated by the virus.1 Microbial resistance involves adaptive (acquired) immunity (e.g., the HLA subtype) or innate (natural) immunity resulting from the genetic makeup of the host.2

With the human immunodeficiency virus (HIV) and its known destruction of the immune system, resistance to infection and disease was not initially expected. However, certain people — long-term . . . [Full Text of this Article]


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From the University of California, San Francisco, San Francisco.


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