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Volume 361:89-92 July 2, 2009 Number 1
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Glucose Control in Critically Ill Patients

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by Inzucchi, S. E.
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by The NICE-SUGAR Study Investigators
-PubMed Citation
To the Editor: In the Normoglycemia in Intensive Care Evaluation–Survival Using Glucose Algorithm Regulation (NICE-SUGAR) study (ClinicalTrials.gov number, NCT00220987 [ClinicalTrials.gov] ), reported by Finfer et al. (March 26 issue),1 intensive glucose control increased mortality. These findings are clearly at variance with the decreased mortality that we reported from our center in Leuven, Belgium.2,3,4 Finfer et al. do not address several possible explanations for this discrepancy.

First, normoglycemia (blood glucose level, <110 mg per deciliter [6.1 mmol per liter]) was compared with distinct blood glucose control with target ranges of 140 to 180 mg per deciliter (7.8 to 10.0 mmol per liter) . . . [Full Text of this Article]



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