Despite the pervasive measurement of cardiac troponin for thediagnosis of myocardial infarction, the continued evolutionof assays and guidelines for their application has created uncertaintyamong many practitioners regarding the use of cutoff valuesfor clinical interpretation. As such, many clinicians may notwelcome more sensitive assays for troponin. Nevertheless, professionalsocieties have advocated for improved analytic performance ofcommercial assays, resulting in a current generation of widelyused troponin assays that are more sensitive than their predecessors.In this issue of the Journal, important studies by Keller etal.1 and Reichlin et al.2 reveal the advantages and limitations. . . [Full Text of this Article]
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From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston.