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Published at www.nejm.org June 6, 2008 (10.1056/NEJMe0804182)

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Diabetes is associated with a reduced lifespan, largely as a consequence of cardiovascular disease.^1,2,3 Although diabetes significantly increases the risk of cardiovascular events,¹ the relative increase in events for each percent increase in glycated hemoglobin is modest.⁴ Microvascular complications of diabetes remain the leading causes of blindness and renal failure in the developed world and are much more closely associated with hyperglycemia than with macrovascular complications.⁴

Though there is a link between hyperglycemia and cardiovascular risk, there is less evidence that glucose lowering is associated with reduction in risk. Patients with type 2 diabetes whose glycated hemoglobin levels were reduced . . . [Full Text of this Article]

Source Information

Drs. Dluhy and McMahon are editors at the Journal.

This article (10.1056/NEJMe0804182) was published at www.nejm.org on June 6, 2008. It will appear in the June 12 issue of the Journal.

This article has been cited by other articles:

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