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Published at www.nejm.org July 23, 2008 (10.1056/NEJMe0805136)

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In the United States alone, it is estimated that adverse drug reactions affect nearly 2 million patients and kill about 100,000 people each year.¹ Adverse drug reactions are often classified into two groups. The first group can be explained by the mode of action of the therapeutic drug. Examples of adverse drug reactions in this group include hypoglycemia induced by diabetic drugs, leukopenia induced by cytotoxic anticancer drugs, and bleeding induced by warfarin, an oral anticoagulant. The phenotypes of the second group are not explained by the mode of action of the drug. Examples in this group are toxic epidermal . . . [Full Text of this Article]

Source Information

From the Human Genome Center, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato, Tokyo.

This article (10.1056/NEJMe0805136) was published at www.nejm.org on July 23, 2008. It will appear in the August 21 issue of the Journal.

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